Professor Xiao-Yuan LI (Ph.D, M.A., Princeton; B.Sc.,
Tel: (852) 2358-7356; Fax: (852) 2358-1594
Bio-physical, Bio-analytical and Bio-inorganic chemistry
Prof. Li¡¦s main interest is in the chemistry problems derived from life sciences. The main research approaches include Bio-physical (linear and nonlinear Raman spectroscopies),Bio-analytical (electrochemical and optical sensing methods)and bio-inorganic(synthesis and characterization of bio-mimetic models for the active sites of metallo-enzymes). An important aspect of our research approach is to fabricate functional nano-structured materials with novel optical and electrochemical properties and to explore their applications in bio-physical and bio-analytical chemistry.
Representative Publications- Biophysical and Bioanalytical Chemistry
"Synergistic Neuroprotection by Bis(7)-tacrine via Concurrent Blockade of N-Methyl-D-aspartate Receptors and Neuronal Nitric Oxide Synthase" Molecular Pharmacology, 71: 1258-1267 (2007).
"Dendritic Nanostructures of Silver: Facile Synthesis, Structural Characterizations, and Sensing Applications" Langmuir 22, 4836-4842 (2006).
"Surface-enhanced hyper Raman and Surface-enhanced Raman Scattering from Molecules Adsorbed on Nanoparticles-on-Smooth-Electrode (NOSE) Substrate. Pyridine, Pyrazine and Benzene" J. Raman Spectrosc. 36: 555-573 (2005).
"Polyelectrolyte Multilayer as Matrix for Electrochemical Deposition of Gold Clusters: Toward Super-Hydrophobic Surface" J. Am. Chem. Soc., 126: 3064-3065 (2004).
- Bioinorganic, Biomimetic Catalysis, Nanomaterials :
"Converting Cytochrome c into a Peroxidase-Like Metalloenzyme by Molecular Design" ChemBioChem 8: 607¡V609(2007).
"Synthesis, crystal structure and nuclease activities of copper(II) complexes with asymmetric tridentate ligands" J. Inorg. Biochem., 98, 423-429 (2004).
"Synthesis and Characterization of Aqua-bridged Dimetallic Complexes, M2(m-H2O)(-OAc)2(Im)4(OAc)2 (M = Mg2+, Mn2+, and Ni2+) ¡V Structural Models for the Active Sites of Dimetallic Hydrolases" J. Inorg. Biochem. 92(2): 128-136 (2002).
"The Design of New Molecular Light Swithces for DNA" J. Biol. Inorg. Chem., 6(2), 143-150 (2001).