Associate Professor, Zhihong GUO (Ph.D, Minnesota, 1988 )


E-mail: "chguo@ust.hk"
Tel: (852) 2358-7352; Fax: (852) 2358-1594

Research Interests

Bioorganic chemistry and chemical biology 

Dr. Guos research interests include: (1) the effects of macromolecular crowding on the structure, function, and supramolecular organization of proteins; (2) identification, characterization, catalytic mechanism, and organization of enzymes involved in the biosynthesis of menaquinone; (3) development of drug leads inhibiting menaquinone biosynthesis as a means to combat microbial resistance; and (4) the roles of 3a protein in the pathogenesis of the infections by severe acute respiratory syndrome (SARS) coronavirus. Postgraduate students in the research group receive extensive training in bioorganic chemistry, protein chemistry, enzymology, molecular biology, and cell biology.

Representative Publications

"Identification and characterization of (1R, 6R)-2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli" Biochemistry, 47, 3426V3434 (2008).

"Suppression of linear side products by macromolecular crowding in nonribosomal enterobactin biosynthesis" Org. Lett., 10, 649V652 (2008).

"Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic acid, a key intermediate in menaquinone biosynthesis" Org. Lett., 9, 4765V4767 (2007).

"Menaquinone biosynthesis in Escherichia coli: Identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity" Biochemistry, 46, 10979V10989 (2007).

"Effects of macromolecular crowding on the intrinsic catalytic efficiency and structure of enterobactin-specific isochorismate synthase" J. Am. Chem. Soc., 129, 730V731 (2007).

"Amino terminus of the SARS coronavirus protein 3a elicited strong, potentially protective humoral responses in infected patients" J. Gen. Virol., 87, 369V374 (2006).

"B cell responses in patients who have recovered from severe acute respiratory syndrome target a dominant site in the S2 domain of the surface spike glycoprotein" J. Virol., 79, 3401V3408 (2005).

"Optimization of antibacterial cyclic decapeptides" J. Comb. Chem., 6, 398V406 (2004).